Tirzepatide (mounjaro) 5mg 10mg 15mg txhaj
Tirzepatide
Tirzepatide yog ib qho kev tshawb nrhiav ib zaug ib lub lim tiam, dual qabzib-nyob ntawm insulinotropic polypeptide thiab glucagon-zoo li peptide-1 receptor agonist uas sib xyaw ua ke ntawm ob qho tib si incretins rau hauv ib qho molecule.
Tirzepatide Mimics Natural Hormones uas txhawb nqa kev xav puv
Tirzepatide ua haujlwm los ntawm kev ua raws li GLP-1 thiab GIP cov tshuaj hormones uas tau tso tawm los ntawm txoj hnyuv tom qab noj mov, uas ua rau muaj kev tso tawm insulin.Nws kuj tseem txo qis qab los noj mov los ntawm kev qeeb qeeb lub sijhawm nws yuav siv lub plab kom khoob thiab cuam tshuam nrog thaj chaw hauv lub hlwb harboring GLP-1 receptors kom teeb liab satiety.
Tirzepatide yog ib qho tshuaj tshiab uas FDA pom zoo rau kev kho mob ntshav qab zib hom 2.Muab nws lub zog poob phaus zog,tshuaj tiv thaivsiv off-label rau kev kho mob rog.Nws ua haujlwm li ob GLP-1 agonist thiab GIP agonist kom ua kom muaj txiaj ntsig zoo sib xws uas tau pom nrog GLP-1 cov tshuaj xws li semaglutide.Tam sim no nws tau siv los ua cov tshuaj ntshav qab zib thib ob, zoo ib yam li cov tshuaj GLP-1, thiab muab ua ib zaug ib lub lim tiam subcutaneous txhaj tshuaj.
Tirzepatide yog cov piam thaj-dependent insulinotropic polypeptide (GIP) receptor thiab glucagon-zoo li peptide-1 (GLP-1) recepto agonist, uas yog FDA pom zoo los kho hom 2 mob ntshav qab zib mellitus.Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias tirzepatide tsis raug pom zoo rau kev kho mob ntshav qab zib hom 1 thiab tsis tau kawm hauv cov neeg mob pancreatitis.Tirzepatide yog GIP receptor thiab GLP-1 receptor agonist, ua rau txhim kho glycemic tswj hauv hom 2 mob ntshav qab zib thiab txo qhov hnyav hnyav.
FDA pom zoo Tirzepatide nyob rau lub Tsib Hlis 2022. Tirzepatide kuj tseem tuaj yeem siv los ntawm daim ntawv lo los kho kev rog.Tam sim no nws tau siv los ua cov tshuaj ntshav qab zib thib ob, zoo ib yam li GLP-1 cov tshuaj zoo li semaglutide.Nws yog ib zaug-ib-lub lim tiam subcutaneous txhaj tshuaj nrog incremental koob tshuaj.
Cov ntaub ntawv kho mob tam sim no tau pom tias tirzepatide zoo dua rau cov placebo hauv kev txhim kho hemoglobin A1C qib.Qhov kev sim SURPASS-5 tau pom tias txo qis -2.11% hauv hemoglobin A1C qib ntawm 5mg ib lub lis piam noj, piv rau -0.86% nrog cov placebo.Ntawm qhov koob tshuaj ntau tshaj ntawm 15 mg ib lub lis piam, tirzepatide ua rau txo qis -2.34% hemoglobin A1C.Qhov no tau tshwm sim dhau 40 lub lis piam.Kev txo qhov hnyav ntawm 5.4 kg tau pom nrog 5mg ntawm tirzepatide koob tshuaj, thiab kev txo qis 10.5 kg tau pom nrog 15 mg koob tshuaj.Qhov kev sib raug zoo ntawm koob tshuaj no nrog kev poob phaus zoo ib yam li semaglutide, ib hom tshuaj GLP-1 siv los tswj kev poob phaus.
Piv txwv li, tirzepatide tau pom tias ua haujlwm zoo ib yam li cov tshuaj GLP-1 tab sis muaj txiaj ntsig zoo dua.Muab nws cov txiaj ntsig poob phaus thiab tsis muaj lub siab toxicity, nws zoo li yuav ua lub luag haujlwm tsis ncaj rau hauv kev kho mob ntawm cov kab mob uas tsis yog-coholic fatty siab (NAFLD) thiab.
Nco tseg
Peb xa khoom thoob plaws ntiaj teb.
Koj raug qhia kom sab laj koj qhov kev sab laj kho mob ua ntej siv cov khoom.