Dab tsi yog S-4 (Andrarine)

S-4, marketed asandarine, yog ib qho kev hais lus bioavailable, uas tsis yog-steroidal xaiv androgen receptor modulator (SARM).Andarine yog ib feem agonist ntawm androgen receptor.

S-4 zoo li lwm yam SARMS tau tsim nyob rau hauv thaum ntxov 2000s, nyob rau hauv ib qho kev sim kom kov yeej cov tshuaj pharmacologic thiab pharmacokinetic txwv ntawm steroidal androgen receptor agonists (ie, testosterone thiab DHT), uas tau paub cov koom haum nrog daim siab thiab lub plawv mob.

Compound S-4 tau siv rau hauv kev tshawb fawb tsiaj tab sis raug tso tseg ua ntej ib theem I tib neeg kev sim tshuaj, vim qhov tsis pom kev.Cov teebmeem no tshwm sim thaum S-4 molecule khi rau cov receptors hauv qhov muag;qhov hnyav dua qhov khi, qhov tsis xis nyob ntau dua uas tau ntsib.Kev pom kev cuam tshuam tau pom tias muaj ntau heev, vim muaj kev ua haujlwm tshwj xeeb, rau cov tshuaj uas qhov kev sim siab raug tso tseg.

Ua li casS4Andarine Ua Haujlwm

Ib tug ntawm cov tswv yim mechanisms ntawmS4, yog tias nws tag nrho thaiv kev khi ntawm DHT.Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone los yog stanolone) yog ib qho endogenous androgen deev hormone.txheeb ze rau testosterone, DHT yog qhov muaj zog ntau dua li agonist ntawm androgen receptor.

S-4 muaj lub siab androgen receptor (AR) binding affinity.Cov kev tshawb fawb tau pom tias S-4 tsis muaj zog thiab muaj txiaj ntsig zoo dua li testosterone propionate (TP) hauv kev ua haujlwm androgenic, tab sis lawv cov haujlwm anabolic zoo ib yam li lossis ntau dua li ntawm TP.

S-4 yog tag nrho androgen receptor agonist hauv cov leeg nqaij, thiab ib feem agonist hauv prostate.Yog li, S-4 muaj zog txhawb kev loj hlob ntawm cov leeg, tab sis tsis tuaj yeem tswj xyuas qhov loj ntawm prostate.Testosterone txhawb cov leeg thiab prostate kev loj hlob mus rau tib yam.S-4 ua rau cov tshuaj luteinizing tseem ceeb (LH) lossis follicle stimulating hormone suppression.

S-4 (andarine) Cov txiaj ntsig

Txawm hais tias muaj ntau qhov kev tshawb nrhiav tau ua tiav, kev tshawb fawb ntau ntxiv tau txuas ntxiv thiab nyob rau theem pib ntawm kev txhim kho.Txoj kev loj hlob ntawm SARMS rau kev kho mob thiab kev kho mob siv raws li ib tug androgen lwm txoj, yog kev cia siab raws li cov ntaub ntawv preclinical.

Tsis zoo li anabolic steroids, uas khi rau androgen receptors hauv ntau cov ntaub so ntswg thoob plaws lub cev, tus neeg SARMs xaiv khi rau androgen receptors hauv qee cov ntaub so ntswg, tab sis tsis nyob hauv lwm tus.Txawm li cas los xij, lawv tseem muaj cov teebmeem androgenic thiab anabolic.

SARMS tsis yog anabolic steroids;es, lawv yog cov ligands hluavtaws uas khi rau androgen receptors.Nyob ntawm lawv cov qauv molecular, lawv ua agonists, ib nrab agonists, thiab antagonists.Nws yog li ntawd nyob rau hauv ib qho kev xaiv, uas SARMS modulate los yog kho kom haum coregulators thiab transcription yam los yog signaling cascade proteins los txhawb kev ua si anabolic.

Cov kev tshawb fawb tau pom tias S-4 yog tag nrho androgen receptor agonist hauv cov leeg nqaij, thiab ib feem agonist hauv prostate, ua rau nws yog ib tus neeg sib tw zoo tshaj plaws rau lwm txoj hauv kev rau steroidal androgen receptor agonists (ie, testosterone thiab DHT), vim muaj kev cuam tshuam tsis zoo. ntawm daim siab, lub plawv, thiab fertility.

Nws yuav tsum raug sau tseg, txawm hais tias SARMS zoo li S4 nce kev ua haujlwm androgen, nws tsis yog tus neeg sib tw siv tau rau kev kho tshuaj hormone hloov, vim nws tsis aromatize rau Estrogen.