Kev poob phaus ntau dua ntawm Tirzepatide Txuas rau Xya Yam

Ntawm 3188 tus neeg mob ntshav qab zib hom 2 uas tau ua raws li lawv cov tirzepatide (Mounjaro, Lilly) kev tswj hwm hauv plaub qhov kev sim piv txwv ntawm tus neeg sawv cev, ib lub hlis twg tau ua tiav tsawg kawg 15% txiav los ntawm lawv lub cev hnyav tom qab 40-42 lub lis piam ntawm kev kho mob, thiab cov kws tshawb fawb pom tau xya lub hauv paus hloov pauv uas tau cuam tshuam nrog qhov tshwm sim ntau dua ntawm qib kev poob phaus.

"Cov kev tshawb pom no pab qhia cov neeg uas muaj ntshav qab zib hom 2 feem ntau yuav ua tiav qhov hnyav dua lub cev nrog kev txhim kho cardiometabolic txaus ntshai nrog tirzepatide," hais tias cov sau phau ntawv.

METHODOLOGY:

• Cov neeg tshawb xyuas tau ua qhov kev soj ntsuam tom qab cov ntaub ntawv sau los ntawm tag nrho ntawm 3188 tus neeg mob ntshav qab zib hom 2 uas tau ua raws li lawv txoj cai tirzepatide rau 40-42 lub lis piam hauv ib qho ntawm plaub qhov kev sim piv txwv ntawm tus neeg sawv cev: SURPASS-1, SURPASS- 2, SURPASS-3, thiab SURPASS-4.
• Cov kws tshawb fawb tau tsom los txheeb xyuas qhov kev kwv yees ntawm kev txo qis hauv lub cev qhov hnyav tsawg kawg 15% nrog kev kho mob tirzepatide ntawm ib qho ntawm peb koob tshuaj - 5 mg, 10 mg, lossis 15 mg - uas tau muab los ntawm kev txhaj tshuaj subcutaneous ib zaug ib lub lim tiam.
• Tag nrho plaub qhov kev sim uas tau muab cov ntaub ntawv txwv tsis pub muaj kev kho mob ib txhij uas yuav txhawb kev poob phaus, thiab cov neeg suav nrog hauv kev tshuaj ntsuam tsis tau txais cov tshuaj cawm siav rau kev tswj glycemia.
• Qhov kev ntsuas tseem ceeb hauv tag nrho plaub txoj kev tshawb fawb yog lub peev xwm ntawm tirzepatide los txhim kho glycemic tswj ( ntsuas los ntawm qib A1c) piv nrog cov placebo, semaglutide (Ozempic) 1 mg SC ib zaug ib lub lim tiam, insulin degludec (Tresiba, Novo Nordisk), lossis insulin glargine ( Basaglar, Lilly).

TXOJ CAI:

• Ntawm 3188 cov neeg uas tseem ua raws li lawv cov kev tswj hwm tirzepatide rau 40-42 lub lis piam, 792 (25%) tau ntsib qhov hnyav tsawg kawg yog 15% los ntawm cov hauv paus.
• Kev txheeb xyuas ntau yam ntawm cov hauv paus ntsiab lus pom tau hais tias xya yam tseem ceeb tau txuas nrog ≥15% poob phaus: ntau dua tirzepatide koob tshuaj, ua poj niam, yog haiv neeg Dawb lossis Neeg Esxias, muaj hnub nyoog yau, kev kho mob nrog metformin, muaj kev tswj glycemic zoo dua (raws li ntawm qis A1c thiab qis dua cov piam thaj hauv ntshav), thiab muaj cov qib qis lipoprotein cholesterol tsawg.
• Thaum ua raws li, kev ua tiav ntawm tsawg kawg yog 15% txiav hauv lub hauv paus qhov hnyav tau cuam tshuam nrog kev txo qis hauv A1c, ceev ceev cov piam thaj hauv cov ntshav, lub duav ncig, ntshav siab, qib ntshav triglyceride, thiab qib ntshav ntawm lub siab enzyme alanine transaminase. .
  

  Hauv kev xyaum:

  "Cov kev tshawb pom no tuaj yeem muab cov ntaub ntawv tseem ceeb rau cov kws kho mob thiab cov neeg mob ntshav qab zib hom 2 hais txog qhov yuav ua tiav qhov hnyav ntawm lub cev nrog tirzepatide, thiab tseem yuav pab qhia txog kev txhim kho kom pom nyob rau hauv ntau qhov kev pheej hmoo cardiometabolic nrog tirzepatide-ua kom poob phaus. , "cov kws sau ntawv xaus lus hauv lawv daim ntawv tshaj tawm.