Semaglutide yog polypeptide uas cov kws kho mob tau sau rau kev kho mob ntshav qab zib hom 2.FDA tau pom zoo siv Novo Nordisk's Ozempic thiab Rybelsus raws li kev txhaj tshuaj ib zaug ib lim tiam lossis ua ntsiav tshuaj, raws li.Ib zaug ib lub lim tiam ntawm kev txhaj tshuaj ntawm semaglutide nrog lub npe Wegovy tsis ntev los no tau pom zoo raws li kev kho qhov hnyav.
Kev tshawb fawb tshiab tau nthuav tawm ntawm xyoo no European Congress ntawm Obesity (ECO2023, Dublin, 17-20 Tsib Hlis) qhia tau hais tias cov tshuaj rog rog semaglutide muaj txiaj ntsig zoo rau kev poob phaus hauv ntau qhov chaw, 1-xyoo-ntev-ntev-kev tshawb fawb hauv ntiaj teb.Txoj kev tshawb no yog los ntawm Dr Andres Acosta thiab Dr Wissam Ghusn, Precision Medicine for Obesity Program ntawm Mayo Clinic, Rochester, MN, USA thiab cov npoj yaig.
Semaglutide, ib qho glucagon-zoo li peptide-1 (GLP-1) receptor agonist, yog qhov tsis ntev los no FDA pom zoo tshuaj tiv thaiv kev rog.Nws tau pom cov txiaj ntsig tseem ceeb ntawm kev poob phaus hauv ntau qhov kev sim mus sij hawm ntev randomized thiab kev tshawb fawb luv luv hauv ntiaj teb.Txawm li cas los xij, me ntsis paub txog qhov poob phaus thiab cov txiaj ntsig metabolic hauv cov kev tshawb fawb ib nrab ntawm lub ntiaj teb.Hauv qhov kev tshawb fawb no, cov kws sau ntawv tau soj ntsuam cov txiaj ntsig poob phaus cuam tshuam nrog semaglutide hauv cov neeg mob hnyav thiab rog nrog thiab tsis muaj ntshav qab zib hom 2 (T2DM) ntawm 1 xyoo rov qab.
Lawv tau ua qhov kev rov qab los, ntau qhov chaw (Mayo Clinic Tsev Kho Mob: Minnesota, Arizona, thiab Florida) cov ntaub ntawv sau txog kev siv semaglutide rau kev kho mob rog.Lawv suav nrog cov neeg mob uas muaj qhov ntsuas lub cev (BMI) ≥27 kg / m2 (hnyav thiab tag nrho cov BMI siab dua) uas tau muab tshuaj semaglutide subcutaneous txhua lub limtiam ( koob tshuaj 0.25, 0.5, 1, 1.7, 2, 2.4mg; Txawm li cas los xij feem ntau yog nyob rau koob tshuaj ntau dua 2.4mg).Lawv tsis suav cov neeg mob noj lwm yam tshuaj rau kev rog rog, cov uas muaj keeb kwm ntawm kev rog rog, cov neeg mob qog noj ntshav, thiab cov uas cev xeeb tub.
Thawj qhov kawg taw tes yog tag nrho lub cev poob qis feem pua (TBWL%) ntawm 1 xyoos.Cov ntsiab lus thib ob suav nrog kev faib ua feem ntawm cov neeg mob ua tiav ≥5%, ≥10%, ≥15%, thiab ≥20% TBWL%, kev hloov pauv hauv cov metabolism thiab cov hlab plawv tsis zoo (ntshav siab, HbA1c [glycated hemoglobin, ntsuas ntshav qab zib tswj], yoo mov qabzib thiab cov ntshav rog), TBWL% ntawm cov neeg mob uas muaj thiab tsis muaj T2DM, thiab zaus ntawm cov kev mob tshwm sim thaum thawj xyoo ntawm kev kho.
Tag nrho ntawm 305 tus neeg mob tau suav nrog hauv kev tshuaj ntsuam (73% poj niam, txhais tau tias muaj hnub nyoog 49 xyoos, 92% dawb, txhais tau tias BMI 41, 26% nrog T2DM).Cov yam ntxwv hauv paus thiab kev tswj qhov hnyav tuaj xyuas cov ntsiab lus tau nthuav tawm hauv Table 1 tag nrho cov ntsiab lus.Hauv tag nrho pawg, qhov nruab nrab TBWL% yog 13.4% ntawm 1 xyoo (rau 110 tus neeg mob uas muaj cov ntaub ntawv hnyav ntawm 1 xyoo).Cov neeg mob T2DM tau qis dua TBWL% ntawm 10.1% rau 45 ntawm 110 tus neeg mob nrog cov ntaub ntawv ntawm 1 xyoo, piv rau cov tsis muaj T2DM ntawm 16.7% rau 65 ntawm 110 tus neeg mob nrog cov ntaub ntawv ntawm 1 xyoo.
Feem pua ntawm cov neeg mob uas poob ntau dua 5% ntawm lawv lub cev hnyav yog 82%, ntau dua 10% yog 65%, ntau dua 15% yog 41%, thiab ntau dua 20% yog 21% ntawm 1 xyoo.Semaglutide kev kho mob kuj txo qis systolic thiab diastolic ntshav siab los ntawm 6.8 / 2.5 mmHg;tag nrho cov roj (cholesterol) los ntawm 10.2 mg / dL;LDL ntawm 5.1 mg / dL;thiab triglycerides ntawm 17.6 mg / dL.Ib nrab ntawm cov neeg mob tau ntsib kev phiv los ntawm kev siv tshuaj (154/305) nrog rau feem ntau tshaj tawm tias xeev siab (38%) thiab raws plab (9%) (Daim duab 1D).Cov kev mob tshwm sim feem ntau yog mob me me tsis cuam tshuam rau lub neej zoo tab sis hauv 16 qhov xwm txheej lawv tau ua rau txwv tsis pub siv tshuaj.
Cov kws sau ntawv xaus lus: "Semaglutide tau txuam nrog kev poob phaus thiab kev txhim kho metabolic ntawm 1 xyoo hauv ntau qhov kev tshawb fawb hauv ntiaj teb, qhia nws cov txiaj ntsig hauv kev kho mob rog, hauv cov neeg mob thiab tsis muaj T2DM."
Pab pawg Mayo tab tom npaj ob peb lwm cov ntawv sau hais txog semaglutide, suav nrog cov txiaj ntsig ntawm qhov hnyav hauv cov neeg mob uas muaj qhov hnyav rov qab los tom qab phais bariatric;Cov txiaj ntsig poob phaus hauv cov neeg mob uas tau siv lwm cov tshuaj tiv thaiv kev rog yav dhau los piv rau cov uas tsis yog.
Post lub sij hawm: Sep-20-2023